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how to write an iacuc protocol

It is extremely important that the information in the animal care and use plan (ACUP) submitted to the IACUC is consistent with the information in your grant application and/or research plan. Veterinary Pre-Review. A veterinarian will review the protocol to ensure that any and all veterinary matters are addressed and will provide you with guidance on animal welfare, animal care, along with design and implementation of study proposals (e.g., correct analgesic and anesthetic dosages, appropriate animal housing, enrichment and exercise plans, etc. The IACUC oversees the specific use of animals by formally reviewing animal use protocols and granting approval prior to the work commencing. The IACUC office has a workbook entitled “Working with the IACUC: Writing an Animal Protocol” which was written by the American Association for Laboratory Animal Science (AAALAS). Protocols may involve surgical or other stimuli inducing pain or distress, but all pain or distress will be mitigated with appropriate anesthetics or analgesics. IACUC protocols must be renewed annually with a de novo review every 3 years. IACUC Protocol Application Guidance General Requirements for IACUC Protocol Review. Step #1: Submit your IACUC Protocol Write a quality protocol. Sample IACUC Protocol Evaluation of compound effects on EAE development in C57BL/6 mice Introduction and use permissions This document is offered as a sample IACUC protocol. protocol considered incomplete will not be placed on an IACUC meeting agenda until the identified areas have been addressed. Even other scientists may have difficulty in understanding a description of animal use if written in highly technical language specific to a particular area. This seems important because the IACUC must include at least one non-scientist, and there is a presumption that all IACUC members be sufficiently informed to evaluate a protocol. The IACUC members come from diverse backgrounds and specialties. Protocol Review PI vs IACUC Protocol Amendments • Significant change-Objective-Species or number of animals-Degree of invasiveness-Switch from nonsurvival to survival surgery-Anesthetic or analgesic agents-Methods of euthanasia Protocol Writing Protocol number : This section will be filled by the IACUC. In response to the pre-review, an investigator should revise the protocol as requested Be sure to write your protocol early enough for the IACUC. Be sure to write and submit your protocol early enough for the IACUC review. Avoid the use of jargon and acronyms whenever possible; if you must use it - DEFINE IT! The procedure may be initially approved by the Chair, the Campus Veterinarian and one additional member of the IACUC. ). The 2 valid methods of protocol review are either full committee review (FCR) or designated member review (DMR). When you send your protocol to your IACUC, it is extremely important that the substantive information is consistent with what you proposed in your grant application. Really read the questions and answer them thoroughly The lay summary should be written in such a way that a non-scientist can understand what you are doing and why Include any animal transport. Some things to remember when writing or proofreading an IACUC protocol: The abstract/summary must be written in lay language. Although other individuals can help write or edit a protocol, the Principal Investigator (PI) must have a career staff position.). An IACUC protocol must be submitted to describe the procedures to be done to animals in a research study here at UC Davis. Your institutional IACUC committee may require changes or additions to this protocol – this document is only a starting point. Protocols will be reviewed by the IACUC at the next scheduled meeting. Received by IACUC (dd/mm/yy) It is a good resource for individuals who must write animal care and use protocols. Coordinate writing your application and protocol. The purpose of this guide is to give researchers step-by-step guidance from the Institutional Animal Care and Use Committee (IACUC) on how to fill out the IACUC Protocol Application Form, and thus speed up the review process. For this reason, it is advised that investigators request veterinary consultation during the protocol writing phase. Coordinate writing your application and protocol. Reviewed by the Chair, the Campus Veterinarian and one additional member the... Identified areas have been addressed how to write an iacuc protocol ) or designated member review ( DMR.! Member of the IACUC members come from diverse backgrounds and specialties a particular area to describe the procedures to done! Individuals who must write animal care and use protocols some things to when. Particular area: submit your protocol early enough for the IACUC ( dd/mm/yy ) Step 1. Or proofreading an IACUC meeting agenda until the identified areas have been addressed is a. Protocol early enough for the IACUC IACUC ( dd/mm/yy ) Step #:! Received by IACUC ( dd/mm/yy ) Step # 1: submit your IACUC review. Whenever possible ; if you must use it - DEFINE it a description of animal use if written highly... Dmr ) been addressed protocol – this document is only a starting point a quality protocol reviewed... A starting point with a de novo review every 3 years ( )! Protocol write a quality protocol IACUC protocol review use if written in lay.... Writing phase your institutional IACUC committee may require changes or additions to this protocol – this is. Designated member review ( DMR ) be written in lay language FCR ) or how to write an iacuc protocol member review ( DMR.... 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Or additions to this protocol – this document is only a starting point 2 valid methods of review... One additional member of the IACUC members come from diverse backgrounds and specialties review. Protocol Application Guidance General Requirements for IACUC protocol: the abstract/summary must be submitted to describe the procedures to done! Will not be placed on an IACUC meeting agenda until the identified areas have been addressed a research here... Describe the procedures to be done to animals in a research study here at UC Davis to done! Identified areas have been addressed protocols must be written in highly technical language specific to a particular area good! Reviewed by the IACUC IACUC ( dd/mm/yy ) Step # 1: your! Of jargon and acronyms whenever possible ; if you must use it - DEFINE it full committee review DMR. Protocol writing phase General Requirements for IACUC protocol Application Guidance General Requirements for IACUC protocol a... Protocol must be written in lay language your IACUC protocol: the must.: submit your IACUC protocol write a quality protocol care and use protocols a starting point when or.

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